Why the study?
Do prostacyclin, oxygen radical scavengers, or diltiazem prevent myocyte and endothelial injury during ischemia reperfusion in isolated rat hearts?
Population
Isolated rat hearts
Comparison
Prostacyclin, oxygen radical scavengers, or… vs Ischemia reperfusion without protective agents
Design
Preclinical
Follow-up
Up to 30 minutes of ischemia and 20 minutes of reperfusion
Authors
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Should not yet change clinical ischemia-reperfusion management; leaves open translation of diltiazem effects beyond isolated rat hearts.
Do prostacyclin, oxygen radical scavengers, or diltiazem prevent myocyte and endothelial injury during ischemia reperfusion in isolated rat hearts?
In an isolated rat heart model, diltiazem protects both myocyte and endothelial cell functions from ischemia-reperfusion injury, whereas prostacyclin and oxygen radical scavengers do not.
Sunnergren et al. (1987) studied this question.
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