September 20, 2012Journal of Interventional Cardiology
Intracoronary Hemodynamic Effects of Pressure‐Controlled Intermittent Coronary Sinus Occlusion (PICSO): Results from the First‐In‐Man Prepare PICSO Study
Why the study?
Does pressure-controlled intermittent coronary sinus occlusion (PICSO) increase coronary sinus and LAD wedge pressures in patients with stable angina undergoing LAD PCI?
Population
15 patients with stable angina scheduled for percutaneous coronary intervention of the left anterior…
Comparison
Pressure-controlled intermittent coronary sinus… vs Balloon occlusion of the LAD without PICSO for…
Design
Cohort
Follow-up
30 days
Authors
Discussion
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Implication
May support PICSO pressure augmentation during LAD PCI; hypothesis-generating for perfusion benefit, needs randomized trials.
Structured PICO
Does pressure-controlled intermittent coronary sinus occlusion (PICSO) increase coronary sinus and LAD wedge pressures in patients with stable angina undergoing LAD PCI?
P
Population
15 patients with stable angina scheduled for percutaneous coronary intervention (PCI) of the left anterior descending artery (LAD).
I
Intervention
Pressure-controlled intermittent coronary sinus occlusion (PICSO) during balloon occlusion of the LAD for maximally 3 minutes.
C
Comparator
Balloon occlusion of the LAD without PICSO for maximally 3 minutes.
O
Outcome
Coronary sinus (CS) pressure and LAD wedge pressure.surrogate
PICSO safely augments coronary sinus pressure and LAD coronary wedge pressure during PCI, supporting its potential to improve myocardial perfusion.
Cite This Study
Hoef et al. (2012) studied this question.