September 15, 2007AJP Heart and Circulatory Physiology

The balance between inactivation and activation of the Na+-K+pump underlies the triphasic accumulation of extracellular K+during myocardial ischemia

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Population

Dynamic model of cellular electrophysiology simulating myocardial ischemia

Design

Preclinical

Follow-up

15 minutes (simulated)

Authors

JTJonna TerkildsenUniversity of Auckland ECEdmund J. CrampinThe University of Melbourne NSNicolas P. SmithLawrence Berkeley National Laboratory

Discussion

Member takes

Implication

Should not yet change ischemia management; leaves open therapeutic targeting of Na+-K+ pump in human arrhythmias.

Structured PICO

Population

Dynamic model of cellular electrophysiology simulating myocardial ischemia

Intervention

Incorporation of changes in metabolite concentrations during 15 min of zero-flow global ischemia into a metabolically sensitive description of the Na+-K+ pump, ATP-sensitive K+ channel, and cell volume regulation

Outcome

Accumulation of extracellular K+ and its triphasic time coursesurrogate

Computational modeling reveals that inhibition of the Na+-K+ pump is the primary driver of ischemia-induced extracellular potassium accumulation, explaining its triphasic profile.

Cite This Study

Terkildsen et al. (2007) studied this question.

synapsesocial.com/papers/6a713b57fe4101aa97e07cdd https://doi.org/10.1152/ajpheart.00771.2007

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The balance between inactivation and activation of the Na+-K+pump underlies the triphasic accumulation of extracellular K+during myocardial ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The balance between inactivation and activation of the Na+-K+pump underlies the triphasic accumulation of extracellular K+during myocardial ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider