A normal EKG cannot definitively rule out Brugada syndrome, as the characteristic EKG pattern can be unmasked by physiological stress such as fever.
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Fever may transiently unmask Brugada pattern, warranting EKG vigilance in febrile patients; case report leaves open prospective validation of fever provocation.
Brugada syndrome (BS) is a cardiac rhythm disturbance that predisposes patients to sudden cardiac death. Brugada is classically described with specific electrocardiographic (EKG) findings of ST elevation and right bundle branch block in precordial leads and is an often unrecognized contributor to sudden cardiac death. We present a case of BS with cyclic EKG findings in a febrile 20-year-old active duty, Vietnamese male who presented following a witnessed syncopal event. His classic findings of Brugada pattern on EKG demonstrated reversibility with clinical defervescence. In patients with a suggestive history, a normal EKG cannot definitively rule out BS as the Brugada pattern can be unmasked by stress, which in this case was represented by a pneumonia-induced fever.
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Grogan et al. (2011) studied this question.
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