Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 7, 2010Lupus

The endothelium: an interface between autoimmunity and atherosclerosis in systemic lupus erythematosus?

View Full Paper
Ask AI
Bookmark
Share

Population

Patients with systemic lupus erythematosus (SLE)

Design

Review

Authors

CNC. B. NarshiWest Middlesex University HospitalIGI.P. GilesRotherham General HospitalARAnisur RahmanGreater Manchester Mental Health NHS Foundation Trust

Discussion

Loading...

Member takes

Implication

Supports hypothesis of autoantibody-driven atherogenesis in SLE; hypothesis-generating and requires prospective validation before clinical consideration.

Structured PICO

P
Population
Patients with systemic lupus erythematosus (SLE)
O
Outcome
Pathogenesis of atherosclerosis and cardiovascular disease

This review highlights the potential mechanistic role of SLE-associated autoantibodies in driving accelerated atherosclerosis through endothelial dysfunction and lipoprotein alteration.

Cite This Study

Narshi et al. (2010) studied this question.

synapsesocial.com/papers/6a71402126a7f98052dda2eahttps://doi.org/10.1177/0961203310382429
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anticardiolipin Antibodies From Patients With the Antiphospholipid Antibody Syndrome Recognize Epitopes in Both β <sub>2</sub> -Glycoprotein 1 and Oxidized Low-Density Lipoprotein2001 · 65 citations
  2. 2Antibodies Against Cardiolipin and Oxidatively Modified LDL in 50-Year-Old Men Predict Myocardial Infarction1997 · 219 citations
  3. 3Antibodies to oxidised LDL2000 · 54 citations
  4. 4Cross‐Reactivity of IgM and IgG Anticardiolipin Antibodies with Oxidized‐Low Density Lipoproteins2005 · 20 citations
  5. 5Prevalence of conventional and lupus‐specific risk factors for cardiovascular disease in patients with systemic lupus erythematosus: A case–control study2006 · 106 citations