Key result
Pro-inflammatory HDL and anti-oxidized phospholipid antibodies promote plaque formation, instability, and thrombosis, contributing to accelerated atherosclerosis in systemic lupus erythematosus.
This review highlights the role of pro-inflammatory HDL and oxidized lipid autoantibodies in driving accelerated atherosclerosis and cardiovascular events in patients with systemic lupus erythematosus.
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May support CV risk stratification in SLE; leaves open whether modulating these pathways improves outcomes.
Hahn et al. (2008) conducted a review in Systemic lupus erythematosus and atherosclerosis. Pro-inflammatory HDL (piHDL) and anti-OxPL antibodies vs. Normal HDL / healthy controls was evaluated. Pro-inflammatory HDL and anti-oxidized phospholipid antibodies promote plaque formation, instability, and thrombosis, contributing to accelerated atherosclerosis in systemic lupus erythematosus.
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