February 23, 1998Circulation ResearchOpen Access

ATP-Sensitive K+Channels, Adenosine, and Nitric Oxide–Mediated Mechanisms Account for Coronary Vasodilation During Exercise

View Full Paper

Ask AI

Bookmark

Population

Dogs studied at rest and during a four-stage treadmill exercise protocol

Comparison

Sequential blockade of K+ channels, adenosine… vs Control conditions

Design

Preclinical

Authors

YIYutaka IshibashiAichi Sangyo University DDDirk J. DunckerGeneral Cardiology JZJianyi ZhangGuangzhou University of Chinese Medicine

Discussion

Member takes

Implication

Animal data indicate redundant coronary vasodilator pathways; leaves open translation to human exercise physiology.

Structured PICO

Population

Dogs studied at rest and during a four-stage treadmill exercise protocol

Intervention

Sequential blockade of K+(ATP) channels (glibenclamide 50 microg/kg/min i.c.), adenosine receptors (8-phenyltheophylline 5 mg/kg i.v.), and NO synthase (N(G)-nitro-L-arginine 1.5 mg/kg i.c.)

Comparator

Control conditions (rest and exercise without blockade)

Outcome

Coronary blood flow and coronary vascular conductancesurrogate

K+(ATP) channels are critical for maintaining coronary vasodilation at rest and during exercise, but when blocked, both adenosine and NO act to increase coronary blood flow during exercise.

Cite This Study

Ishibashi et al. (1998) studied this question.

synapsesocial.com/papers/6a7140e61556b380a2271cb2 https://doi.org/10.1161/01.res.82.3.346

View Full Paper

Ask AI

Bookmark

ATP-Sensitive K+Channels, Adenosine, and Nitric Oxide–Mediated Mechanisms Account for Coronary Vasodilation During Exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ATP-Sensitive K+Channels, Adenosine, and Nitric Oxide–Mediated Mechanisms Account for Coronary Vasodilation During Exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider