February 9, 2006Journal of Applied Physiology
Effects of combined inhibition of ATP-sensitive potassium channels, nitric oxide, and prostaglandins on hyperemia during moderate exercise
Key result
Inhibition of KATP channels with glibenclamide did not alter forearm blood flow during exercise, and combined triple blockade reduced flow by approximately 15% in most subjects.
Why the study?
Does combined inhibition of KATP channels, NO, and prostaglandins alter forearm blood flow during moderate exercise in healthy young adults?
Population
18 healthy young adults
Comparison
Brachial artery infusion of glibenclamide (10… vs Steady-state forearm blood flow during saline…
Design
Other
Follow-up
20 minutes
Authors
Discussion
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Implication
Hypothesis-generating for KATP in human exercise hyperemia; larger studies needed before clinical relevance.
Structured PICO
Does combined inhibition of KATP channels, NO, and prostaglandins alter forearm blood flow during moderate exercise in healthy young adults?
P
Population
18 healthy young adults who performed moderate dynamic forearm exercise to assess the regulation of exercise hyperemia.
I
Intervention
Brachial artery infusion of glibenclamide (10 microg.dl(-1).min(-1)) for 5 min alone (n=9) or followed by combined infusion of L-NAME plus ketorolac (n=9) during moderate dynamic forearm exercise
C
Comparator
Steady-state forearm blood flow during saline infusion
O
Outcome
Forearm blood flow (FBF) measured via Doppler ultrasoundsurrogate
Opening of KATP channels is not obligatory for forearm exercise hyperemia, and combined blockade of NO, prostaglandins, and KATP channels does not reduce hyperemia more than NO and prostaglandin inhibition in most subjects.
Cite This Study
Schrage et al. (2006) studied Healthy (n=18). Glibenclamide alone or combined with L-NAME and ketorolac vs. Saline control was evaluated on Forearm blood flow (FBF). Inhibition of KATP channels with glibenclamide did not alter forearm blood flow during exercise, and combined triple blockade reduced flow by approximately 15% in most subjects.