Key result
Combined inhibition of KIR channels and Na+/K+-ATPase with barium chloride and ouabain significantly reduced steady-state forearm blood flow during exercise by 20% compared to control.
Why the study?
Does activation of KIR channels and Na(+)-K(+)-ATPase contribute to exercise hyperemia in humans?
Population
Humans undergoing rhythmic handgrip exercise (n=11 in protocol 1, n=8 in protocol 2, n=8 in protocol 3)
Comparison
Combined inhibition of KIR channels and… vs Saline control
Design
Other
Follow-up
5 minutes
Authors
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Supports KIR channels in exercise hyperemia; leaves open therapeutic potential pending further research.
Does activation of KIR channels and Na(+)-K(+)-ATPase contribute to exercise hyperemia in humans?
Effect estimate: -20%
Absolute Event Rate: 133% vs 167%
p-value: p=<0.05
Activation of KIR channels is a novel contributing pathway to exercise hyperemia in humans.
Crecelius et al. (2014) studied Healthy (n=27). Barium chloride and ouabain vs. Saline was evaluated on Steady-state forearm blood flow (FBF) (-20%, p=<0.05). Combined inhibition of KIR channels and Na+/K+-ATPase with barium chloride and ouabain significantly reduced steady-state forearm blood flow during exercise by 20% compared to control.
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