Key result
Combined inhibition of NO, PGs, Na+/K+-ATPase, and KIR channels blunted the compensatory increase in forearm blood flow during hypoxic exercise by ~50% (29 vs 62 mL/min, P<0.05).
Why the study?
Does combined inhibition of NO, PGs, Na+/K+-ATPase and KIR channels blunt augmented hyperaemia during hypoxic exercise in healthy young adults?
Population
Healthy young adults (n=20 total; 10 in Protocol 1, 10 in Protocol 2)
Comparison
Protocol 1: Combined inhibition of NO, PGs… vs Control condition
Design
Other
Authors
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Redundant vasodilator pathways maintain most hyperaemia during hypoxic exercise; hypothesis-generating and leaves clinical translation open.
Does combined inhibition of NO, PGs, Na+/K+-ATPase and KIR channels blunt augmented hyperaemia during hypoxic exercise in healthy young adults?
Absolute Event Rate: 29% vs 62%
p-value: p=<0.05
Activation of Na+/K+-ATPase and KIR channels is required for augmented muscle hyperaemia during hypoxia at rest, but not during hypoxic exercise.
Racine et al. (2018) studied Healthy (n=20). Combined inhibition of NO, PGs, Na+/K+-ATPase and KIR channels (l-NMMA + ketorolac + ouabain + BaCl2) vs. Control was evaluated on Compensatory increase in forearm blood flow (FBF) during hypoxic exercise (p=<0.05). Combined inhibition of NO, PGs, Na+/K+-ATPase, and KIR channels blunted the compensatory increase in forearm blood flow during hypoxic exercise by ~50% (29 vs 62 mL/min, P<0.05).
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