Key result
Combined L-NMMA and aminophylline did not significantly reduce forearm vascular conductance during 10% hypoxic exercise compared to L-NMMA alone (-21.4% vs -17.5%; P=0.28).
Why the study?
Does intra-arterial L-NMMA with or without aminophylline attenuate augmented vasodilatation during hypoxic exercise?
Does intra-arterial L-NMMA with or without aminophylline attenuate augmented vasodilatation during hypoxic exercise?
Absolute Event Rate: -21.4% vs -17.5%
p-value: p=0.28
Nitric oxide contributes to augmented vasodilatation during hypoxic exercise independent of adenosine receptor activation.
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May inform mechanisms of hypoxic vasodilatation; leaves open any clinical relevance of NO or adenosine inhibition.
Casey et al. (2009) studied this question. L-NMMA and combined L-NMMA-aminophylline vs. Saline was evaluated on Relative reduction in change in forearm vascular conductance (DeltaFVC) during 10% hypoxic exercise (p=0.28). Combined L-NMMA and aminophylline did not significantly reduce forearm vascular conductance during 10% hypoxic exercise compared to L-NMMA alone (-21.4% vs -17.5%; P=0.28).
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