Population
Psoas myofibrils (chemically cross-linked as a model for isometric contraction)
Comparison
Chemical cross-linking to prevent shortening vs Relaxed or rapidly shortening myofibrils
Design
Preclinical
Authors
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Pi release limits ATPase in cross-linked myofibrils; leaves open validation in human cardiac muscle and in vivo energetics.
Phosphate release, rather than ADP release, appears to be the rate-limiting step in the ATPase cycle of skeletal myofibrils during isometric contraction.
Lionne et al. (2002) studied this question.
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