May 25, 1982Biochemistry

Dimerization of the myosin heads in solution

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Population

Skeletal myosin S-1 in solution

Design

Preclinical

Authors

JMJean E. MorelÉcole Centrale Paris MGManuel GarrigosCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Alerts to condition-sensitive myosin equilibria in vitro; leaves open cardiac muscle relevance and therapeutic translation.

Structured PICO

Population

Skeletal myosin S-1 in solution

Intervention

Varying hydrostatic pressure, temperature, and buffer composition (pH, ionic strength, Mg-phosphate compounds, Mg2+)

Outcome

Monomer-dimer equilibrium and sedimentation coefficientssurrogate

Skeletal myosin S-1 exists in a dynamic monomer-dimer equilibrium that is highly sensitive to environmental conditions such as pH, ionic strength, and the presence of Mg-phosphate compounds.

Cite This Study

Morel et al. (1982) studied this question.

synapsesocial.com/papers/6a71438875498292b70abe73 https://doi.org/10.1021/bi00540a016

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Dimerization of the myosin heads in solution

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dimerization of the myosin heads in solution

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider