The applications of the purified bacterial neurotoxins have not been exploited to their full potential by research workers in the fields of neurophysiology and neuropharmacology. These chemically identified purified proteins have very selective sites of action in the central and autonomic nervous systems. As laboratory tools for the identification of the locus of action of drugs and neurotransmitter substances, these agents have proved to be very useful. Since they are not available from chemical suppliers, agencies such as the Public Health Service and the National Institutes of Health should consider the subsidization of the production of these biological substances in order to make them easily accessible to the nonbacteriologist researcher. In this review the authors have pointed out the problems for future research in this field and they have highlighted the issues confronting the clinician attempting to treat these rare but acute and sometimes fatal poisonings.
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Lamanna et al. (1967) studied this question.