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March 14, 2006Proceedings of the National Academy of SciencesOpen Access

Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B

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Population

Transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B and in vitro…

Design

Preclinical

Authors

TLThomas LangenickelJBJens ButtgereitIPInes Pagel-Langenickel

Discussion

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Overview

No immediate clinical implications from rodent data; leaves open NPR-B role in human cardiac hypertrophy or therapeutic targeting.

Structured PICO

P
Population
Transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B (NPR-BDeltaKC) and in vitro models
I
Intervention
Expression of a dominant-negative mutant of NPR-B (NPR-BDeltaKC)
O
Outcome
Cardiac hypertrophy and heart ratesurrogate

This study provides evidence linking NPR-B signaling to the control of cardiac growth, suggesting its impairment leads to cardiac hypertrophy.

Cite This Study

Langenickel et al. (2006) studied this question.

synapsesocial.com/papers/6a71466df44fa9f079df0efahttps://doi.org/10.1073/pnas.0510019103
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Also Consider

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  1. 1Mechanisms of natriuretic-peptide-induced growth inhibition of vascular smooth muscle cells1997 · 83 citations
  2. 2Expression of Constitutively Active Guanylate Cyclase in Cardiomyocytes Inhibits the Hypertrophic Effects of Isoproterenol and Aortic Constriction on Mouse Hearts2003 · 85 citations
  3. 3Low-Dose C-Type Natriuretic Peptide Does Not Affect Cardiac and Renal Function in Humans1998 · 48 citations
  4. 4Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of "vascular natriuretic peptide system".1992 · 528 citations
  5. 5Further attenuation of endothelium-dependent relaxation imparted by natriuretic peptide receptor antagonism1999 · 37 citations