Population
Mice with congestive heart failure induced by transaortic banding, and nonfailing control mice.
Comparison
Measurement of ANP/NPR-A-dependent and… vs Nonfailing hearts.
Design
Preclinical
Authors
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NPR-B predominance in failing hearts supports dual NPR-A/B agonist development; animal data leave clinical translation open.
NPR-B accounts for the majority of natriuretic peptide-dependent guanylyl cyclase activity in the failing heart, suggesting dual NPR-A/B agonists may be more effective than selective NPR-A agonists like nesiritide.
Dickey et al. (2007) studied this question.
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