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March 1, 1997AJP Heart and Circulatory Physiology

Measurement of intraventricular pressure and cardiac performance in the intact closed-chest anesthetized mouse

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Population

Euthyroid, hypothyroid, and hyperthyroid anesthetized mice

Comparison

Instrumentation with polyethylene catheters and… vs Euthyroid control animals

Design

Preclinical

Authors

JLJohn N. LorenzHeart Failure / CardiomyopathyJRJeffrey RobbinsUniversity of Vermont

Discussion

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Implication

Should not change clinical practice; hypothesis-generating for thyroid effects on contractility in translational models.

Structured PICO

P
Population
Euthyroid, hypothyroid, and hyperthyroid anesthetized mice
I
Intervention
Instrumentation with polyethylene catheters and a Millar MIKRO-TIP transducer in the left ventricle via the right carotid artery, and isoproterenol administration
C
Comparator
Euthyroid control animals
O
Outcome
Isovolumic indexes of myocardial contractility and relaxation derived from the left ventricular pressure pulse and its first derivativesurrogate

The study demonstrates the feasibility of using a high-fidelity microtip manometer to obtain accurate recordings of cardiac performance in fully intact, closed-chest mice.

Cite This Study

Lorenz et al. (1997) studied this question.

synapsesocial.com/papers/6a71466e2163a0a01bc56e7chttps://doi.org/10.1152/ajpheart.1997.272.3.h1137
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