October 1, 1993AJP Heart and Circulatory Physiology
Comparison of normal, hypodynamic, and hyperdynamic mouse hearts using isolated work-performing heart preparations
Population
Isolated work-performing mouse heart preparations from euthyroid, hypothyroid, and hyperthyroid mice across…
Comparison
Induction of hypothyroid and hyperthyroid… vs Normal (euthyroid) control mouse hearts
Design
Preclinical
Authors
Discussion
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Implication
Mouse data show thyroid effects on myocardial performance are only partly beta-adrenergically mediated; leaves open human translation and mechanisms.
Structured PICO
P
Population
Isolated work-performing mouse heart preparations from euthyroid, hypothyroid, and hyperthyroid mice across three different mouse strains
I
Intervention
Induction of hypothyroid and hyperthyroid states, and pharmacological testing with isoproterenol and sotalol
C
Comparator
Normal (euthyroid) control mouse hearts
O
Outcome
Myocardial performance indicators including time to peak pressure (TPP), time to half-relaxation (RT1/2), and first derivatives of intraventricular pressure (+/- dP/dt)surrogate
This study establishes baseline and altered myocardial performance metrics in isolated mouse hearts, demonstrating that hyperthyroid-induced hyperactivity is only partially mediated by beta-adrenergic pathways.
Cite This Study
Grupp et al. (1993) studied this question.