Pediatic intracranial synovial sarcoma: a case report

Figures

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  Fig. 1. A, B Axial T1WI and T2WI reveal synovial sarcoma in the right frontal lobe, which appears as low-to-high signal intensity with the presence of "triple signal sign" and an "liquid–liquid interface.”The mass causes significant space-occupying effects and surrounding edema in the external capsule. C DWI shows diffusion restriction of solid nodules within the mass with hypointensity. D DTI shows displacement and disruption of the nerve fibers surrounding the mass. E, F, G Axial, coronal, and sagittal contrast-enhanced T1WI showing intense enhancement of solid nodules within the mass, commonly referred to as the "cobblestone sign.”The multiple cystic structures of the mass had intact cyst wall, and the enhancement was variable. H Postoperative axial contrast-enhanced T1WI showed that the tumor had been removed

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  Fig. 2. Histomorphologic, immunohistochemical, and molecular profile of synovial sarcoma in the right frontal lobe. A Microscopy shows bidirectional differentiation characteristics encompassing both spindle and epithelial cell phenotypes. B–E Immunohistochemical staining for Bcl-2+, CD99+, Vimentin+, GFAP− [Original magnification: (A) 200 × ; (B–E)100 ×]. F Fluorescence in situ hybridization (FISH) with a break-apart probe for the SS18 gene shows scattered, separated red and green signals per nucleus in tumor cells (↑), indicating the presence of a t(X;18) translocation