Population
Mature rat carotid bodies in vitro
Comparison
Hypoxia and pharmacological agents vs Baseline/normoxia or pre-drug conditions
Design
Preclinical
Authors
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Questions K+ current changes as primary in carotid body hypoxia sensing; leaves open alternative mechanisms for further animal and human study.
The study demonstrates a dissociation between changes in glomus cell voltage-gated outward currents and afferent nerve activity, suggesting modulation of K+ current by hypoxia is not the primary step initiating the nerve response in rat carotid bodies.
Cheng et al. (1995) studied this question.
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