Why the study?
Does chronic hypoxia alter carotid body glomus cell calcium currents in neonatal rats?
Population
5- to 8-day-old rat pups gestated and born in normoxia or chronic hypoxia, from which carotid body glomus…
Comparison
Chronic hypoxia during gestation and birth vs Normoxia during gestation and birth
Design
Preclinical
Follow-up
5 to 8 days post-birth
Authors
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Supports hypothesis that neonatal hypoxic ventilatory depression is central, not peripheral; leaves open human translation and mechanisms.
Does chronic hypoxia alter carotid body glomus cell calcium currents in neonatal rats?
Chronic hypoxia increases calcium current in carotid body glomus cells of neonatal rats, suggesting that the known depression of acute hypoxic ventilatory reflex responses in neonates by chronic hypoxia occurs centrally rather than peripherally.
Steven C. Hempleman (1996) studied this question.
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