Why the study?
Does the Cepheid GeneXpert enterovirus assay accurately detect enteroviral RNA in cerebrospinal fluid compared to other PCR assays?
Does the Cepheid GeneXpert enterovirus assay accurately detect enteroviral RNA in cerebrospinal fluid compared to other PCR assays?
The GeneXpert enterovirus assay demonstrates high sensitivity and specificity for detecting enteroviral RNA in cerebrospinal fluid, comparable to other established PCR methods.
Supports accurate CSF enterovirus detection; leaves open prospective outcome validation before routine adoption.
A prospective unblinded comparative evaluation of three assays for the detection of enteroviral RNA performed on 83 positive and 79 negative cerebrospinal fluid samples showed initial and resolved sensitivities of 90.4% and 98.8%, respectively, for the Cepheid GeneXpert enterovirus assay; 94.0% and 97.6%, respectively, for the Argene enterovirus consensus kit; and 100% and 100%, respectively, for an in-house real-time PCR. The initial and resolved specificities were 100% for all three assays.
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Seme et al. (2008) studied this question.
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