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Three syntheses of (2 S , 3 R )‐2,5‐dihydroxy‐3‐methylpentanoic acid (verrucarinic acid) and its derivatives suitably protected for the further transformation to macrocyclic trichothecenes are described. These involve an enantioselective ester hydrolysis by pig liver esterase, a Sharpless epoxidation and an asymmetric hydroboration.
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Herold et al. (1983) studied this question.
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