Why the study?
The strong relationship between Bayés's syndrome and thromboembolic phenomena or dementia raised the question of whether anticoagulation prior to documented AF could prevent A-IAB-associated events.
Does early anticoagulation therapy prevent thromboembolic events and cognitive impairment in patients with Bayés's syndrome prior to documented atrial fibrillation?
Does early anticoagulation therapy prevent thromboembolic events and cognitive impairment in patients with Bayés's syndrome prior to documented atrial fibrillation?
Answers are grounded in this paper and cite their sources.
This review highlights the association between Bayés's syndrome (advanced interatrial block) and thromboembolic events, raising the hypothesis that early anticoagulation before documented atrial fibrillation may be beneficial.
Bayés’s síndrome is a clinical entity based on the association between advanced interatrial block and the development of supraventricular tachyarrhythmia, being atrial fibrillation (AF), most frequent. This association was discovered by Prof. Antoni Bayés de Luna in the’80s. Further studies by other groups found a strong relationship between Bayés’s syndrome and thromboembolic phenomena, being stroke the most serious. Moreover, patients with this syndrome has an increased incidence of cognitive impairment and dementia. This observation triggered the question about whether the use of an anticoagulation therapy prior to the documentation of AF could prevent A-IAB associated thromboembolic events. There are ongoing studies in different phases of development aiming to compare the efficacy of anticoagulation in patients with A-IAB with no prior documentation of AF. The outcomes of these studies will allow determining the efficacy of this early therapeutic intervention, and help deciding the role of anticoagulation in patients with A-IAB and no demonstrated AF.
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Iomini et al. (2021) conducted a review in Bayés syndrome (advanced interatrial block and supraventricular tachyarrhythmias). Advanced interatrial block (Bayés syndrome) vs. Normal P-wave duration / absence of interatrial block was evaluated on Thromboembolic events (stroke) and cognitive impairment/dementia.
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