Calmodulin kinase II initiates arrhythmogenicity during metabolic acidification in murine hearts
Population
Langendorff-perfused whole heart preparations and single cell action potentials using whole-cell…
Comparison
CaMKII inhibitor KN-93 during metabolic… vs Metabolic acidification without KN-93
Design
Preclinical
Authors
Discussion
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Member takes
Implication
KN-93 suppresses acidosis-induced arrhythmias in murine hearts; hypothesis-generating for CaMKII inhibition in clinical arrhythmia prevention.
Structured PICO
P
Population
Langendorff-perfused whole heart preparations and single cell action potentials using whole-cell patch-clamped ventricular myocytes from murine hearts
I
Intervention
CaMKII inhibitor KN-93 (2 microm) during metabolic acidification (lactic acid)
C
Comparator
Metabolic acidification without KN-93
O
Outcome
Arrhythmogenesis (abnormal electrical activity, ventricular tachycardia, spontaneous AP firing, membrane potential oscillations, spontaneous SR Ca2+ release events)surrogate
CaMKII-dependent sarcoplasmic reticular Ca2+ waves are implicated in spontaneous arrhythmic events during metabolic acidification in murine hearts.
Cite This Study
Pedersen et al. (2009) studied this question.