What is the clinical evidence from this study?

Population: Ischaemia/reperfusion injury. Intervention: KN-93 (CaMKII inhibitor) vs. Control (no treatment). Primary outcome: Incidence of ventricular fibrillation and arrhythmia score.

What does this research mean for the field?

CaMKII inhibition with KN-93 decreases the incidence of ventricular fibrillation and improves post-ischaemic contractile recovery in rat hearts, but does not provide additive anti-arrhythmic benefit when combined with simvastatin. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 10, 2010Heart

13 Distinct role of Ca2+–calmodulin-dependent protein kinase II in excitation–contraction coupling under certain conditions

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Key result

CaMKII inhibition with KN-93 reduces VF and improves post-ischemic contractile function in rat hearts.

Structured PICO

Population

Rat hearts subjected to ischaemia and reperfusion to evaluate the effects of CaMKII inhibition on arrhythmias and contractile function.

Intervention

KN-93 (0.5 μ/l), a CaMKII inhibitor, administered into the perfusion solution before ischemia and during the first 10 min of reperfusion (with or without prior simvastatin 10 mg/kg for 7 days)

Comparator

Control rat hearts without KN-93 treatment, and simvastatin-treated hearts without KN-93

Outcome

Incidence of ventricular fibrillation, arrhythmia score, and recovery of post-ischemic contractile functionsurrogate

CaMKII inhibition reduces ischemia-induced arrhythmias and improves contractility, but may have distinct, potentially adverse effects on contractility in the setting of statin-mediated cardioprotection.

Discussion

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Implication

Should not change clinical practice; hypothesis-generating for CaMKII inhibition in ischemic arrhythmias.

Cite This Study

Adameová et al. (2010) studied Ischaemia/reperfusion injury. KN-93 (CaMKII inhibitor) vs. Control (no treatment) was evaluated on Incidence of ventricular fibrillation and arrhythmia score. CaMKII inhibition with KN-93 decreased the incidence of ventricular fibrillation and improved post-ischaemic contractile function in rat hearts.

synapsesocial.com/papers/6aa9211e5f8760adb38cb272 https://doi.org/10.1136/hrt.2010.213496.13

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13 Distinct role of Ca2+–calmodulin-dependent protein kinase II in excitation–contraction coupling under certain conditions

Structured PICO

Discussion

Implication

Cite This Study

13 Distinct role of Ca2+–calmodulin-dependent protein kinase II in excitation–contraction coupling under certain conditions

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider