Population
Mechanically skinned fibres from normal and dystrophic human muscle
Comparison
Activation in Ca2+- and Sr2+-buffered solutions… vs Normal human muscle fibres
Design
Preclinical
Authors
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May underlie DMD weakness; leaves open human translation and fiber-targeted therapies.
Duchenne muscular dystrophy leads to a marked reduction in the tension-developing ability of individual skeletal muscle fibres and alters overall fibre-type distribution.
Fink et al. (1990) studied this question.
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