Why the study?
Does the lack of PKCepsilon prevent pressure overload-induced myocardial hypertrophy in mice?
Population
PKCepsilon-knockout (KO) and wild-type (WT) mice
Comparison
Transverse aortic constriction to induce… vs Wild-type (WT) mice subjected to TAC
Design
Preclinical
Authors
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PKCε knockout fails to prevent TAC-induced hypertrophy in mice but worsens fibrosis and diastolic dysfunction; leaves open its therapeutic relevance in human pressure overload.
Does the lack of PKCepsilon prevent pressure overload-induced myocardial hypertrophy in mice?
PKCepsilon is not required for pressure overload-induced myocardial hypertrophy, but its absence leads to compensatory pathways that increase fibrosis and impair diastolic function.
Klein et al. (2005) studied this question.
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