February 25, 2002The Journal of Cell BiologyOpen Access

PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal–regulated kinase1/2 (ERK1/2)

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Population

Cultured neonatal rat cardiomyocytes

Design

Preclinical

Authors

Discussion

Hypothesis-generating for PKCα inhibition in hypertrophy; leaves open clinical translation pending human studies.

Population

Cultured neonatal rat cardiomyocytes

Intervention

Adenoviral-mediated gene transfer of wild-type and dominant negative mutants of PKC alpha, beta II, delta, and epsilon (and wild-type zeta)

Outcome

Cardiomyocyte hypertrophic growth (measured by cell surface area, [(3)H]-leucine incorporation, and atrial natriuretic factor expression)surrogate

PKC alpha is a necessary mediator of cardiomyocyte hypertrophic growth, acting in part through an ERK1/2-dependent signaling pathway.

Braz et al. (2002) studied this question.

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