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July 24, 2004AJP Heart and Circulatory Physiology

Protein kinase C-α-induced hypertrophy of neonatal rat ventricular myocytes

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Population

Neonatal rat ventricular myocytes (NRVMs)

Comparison

Replication-defective adenoviruses expressing… vs Uninfected cells or control AdV…

Design

Preclinical

Authors

KVKalpana VijayanESErika L. SzotekJMJoel W. Martin

Discussion

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Overview

Implicates PKC-alpha in cardiomyocyte hypertrophy; leaves open translation to adult or in vivo models.

Structured PICO

P
Population
Neonatal rat ventricular myocytes (NRVMs)
I
Intervention
Replication-defective adenoviruses (AdVs) expressing wild-type (WT) and dominant-negative (DN) PKC-alpha, with or without phorbol myristate acetate (PMA)
C
Comparator
Uninfected cells or control AdV beta-galactosidase (AdV betagal)-infected cells
O
Outcome
Hypertrophic phenotype parameters including protein synthesis, protein-to-DNA (P/D) ratio, cell surface area (CSA), and cell shapesurrogate

PKC-alpha is necessary for specific aspects of phorbol ester-induced hypertrophy in neonatal rat ventricular myocytes, including protein synthesis and cell surface area increases.

Cite This Study

Vijayan et al. (2004) studied this question.

synapsesocial.com/papers/6a7cdf036d67ce102e8d1a7bhttps://doi.org/10.1152/ajpheart.00171.2004
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