July 1, 2003AJP Cell Physiology

Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes

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Population

Cultured neonatal rat ventricular myocytes (NRVM)

Comparison

Adenoviral vectors encoding wild-type and… vs Control levels

Design

Preclinical

Authors

MPMichael PorterJames Hutton Institute MHMaria C. HeidkampLoyola University Chicago BSBrian T. ScullyAgricultural Research Service

Discussion

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Implication

Hypothesis-generating for PKC-SERCA2 regulation in cardiomyocytes; leaves open relevance to human heart failure.

Structured PICO

Population

Cultured neonatal rat ventricular myocytes (NRVM)

Intervention

Adenoviral vectors encoding wild-type (wt) and kinase-defective, dominant negative (dn) mutant forms of PKCalpha, PKCepsilon, and PKCdelta, with or without phorbol 12-myristate 13-acetate (PMA) treatment

Comparator

Control levels

Outcome

SERCA2 mRNA levelssurrogate

The novel PKC isoenzymes PKCepsilon and PKCdelta selectively regulate SERCA2 gene expression in cardiomyocytes, providing insight into mechanisms of abnormal myocardial relaxation in heart failure.

Cite This Study

Porter et al. (2003) studied this question.

synapsesocial.com/papers/6a72bf74f44fa9f079e01d32 https://doi.org/10.1152/ajpcell.00461.2002

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Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider