Why the study?
The origin of complex irregular dynamics in the cardiovascular system remains actively debated between stochastic modulation versus chaotic deterministic dynamics of cardiac pacemakers.
This computational study suggests that the complex, chaotic dynamics of heart rate variability originate primarily from autonomic control loops rather than stochastic modulation.
Model reproduces experimental Lyapunov exponents and correlation dimensions; leaves open stochastic vs deterministic drivers of heart rate variability.
The origin of complex irregular dynamics in a cardiovascular system is still being actively debated. Some hypotheses suggest the crucial role of stochastic modulation of cardiovascular parameters, while others argue for the importance of cardiac pacemakers' chaotic deterministic dynamics. In the present study, we estimate the largest Lyapunov exponent and the correlation dimension for the 4-h experimental interbeat intervals and the chaotic signals generated by the mathematical model of the cardiovascular system. We study the complexity of the mathematical model for such cases as the autonomic blockade, the exclusion of all the stochastic components, and the absence of variability of respiration. The obtained results suggest that the complexity of the heart rate variability is largely due to the chaotic dynamics in the loops of autonomic control of circulation.
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Karavaev et al. (2019) studied this question.
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