Why the study?
AF and cancer frequently coexist and each is associated with increased morbidity and mortality, but synthesized data on arterial thromboembolism, bleeding, and mortality were needed.
Does the presence of comorbid cancer increase the risk of arterial thromboembolism, bleeding, and mortality in patients with atrial fibrillation?
Does the presence of comorbid cancer increase the risk of arterial thromboembolism, bleeding, and mortality in patients with atrial fibrillation?
In patients with atrial fibrillation, comorbid cancer is associated with an increased risk of bleeding and all-cause mortality, but a similar risk of arterial thromboembolism compared to those without cancer.
May warrant closer monitoring in atrial fibrillation with cancer; extends pooled observational evidence on risks.
AIMS: Atrial fibrillation (AF) and cancer often co-exist. Each has been associated with an increased risk of morbidity and mortality. The aim of this meta-analysis was to synthesize available data regarding the incidence of arterial thromboembolism (TE), bleeding, and all-cause mortality in patients with AF with or without cancer. METHODS: Literature search was conducted in PubMed, Ovid MEDLINE, WebOfScience, Scopus, CENTRAL, OpenGrey, and EThOS databases to identify studies that included patients with AF and accounted for cancer status with the incidence of TE (ischemic stroke, transient ischemic attack, or arterial thrombosis), major or clinically relevant non-major bleeding, and all-cause mortality. A random-effects meta-analysis was used. RESULTS: = 98%) were significantly higher in patients with AF with cancer than in patients with AF only. The history of TE and hypertension and mean age were significant moderators of TE risk. CONCLUSION: In patients with AF, the presence of cancer is associated with a similar risk of TE as well as an increased risk of bleeding and all-cause death compared with the absence of cancer.
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Balomenakis et al. (2023) studied this question.
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