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December 1, 1991Diabetes

Islet Function in Offspring of Mothers on Low-Protein Diet During Gestation

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Authors

SDS. DahriMohammed V UniversityASAnne SnoeckUCLouvainBRB. Reusens-BillenUCLouvain

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Implication

Preclinical study reveals permanent islet dysfunction and impaired glucose tolerance in offspring exposed to maternal protein restriction, highlighting long-term metabolic programming.

Key Points

  • To determine how maternal protein restriction during gestation affects fetal endocrine pancreas structure and alters postnatal islet secretory function.
  • Pregnant rats received either a low-protein diet (8%) or a control diet (20%) throughout gestation.
  • Fetal endocrine pancreas morphology, cell proliferation, vascularization, and amino acid-stimulated (arginine and leucine) insulin secretion were evaluated in vitro at 21.5 gestational days.
  • Offspring were evaluated at 70 days of age for blood glucose, fasting insulin, and oral glucose tolerance while maintained on a low-protein diet or after receiving a normal diet from birth.
  • Fetal exposure to a low-protein diet reduced islet size, islet vascularization, cell proliferation, and overall pancreatic insulin content at 21.5 days of gestation.
  • Fetal islets from protein-restricted pregnancies exhibited impaired in vitro insulin secretion when challenged with arginine and leucine.
  • Offspring maintained on a low-protein diet showed low fasting insulin and impaired glucose tolerance at 70 days, a defect not rescued by postnatal restoration of a normal diet.

Cite This Study

Dahri et al. (1991) studied this question.

synapsesocial.com/papers/6a714ace78a11c550e0b5934https://doi.org/10.2337/diab.40.2.s115
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 11727-P: Low-Protein Diet during Pregnancy and Lactation May Impair Islet Function of the Female Offspring Mice Potentially Due to Islet Epigenetic Changes2024
  2. 2A low-protein maternal diet during gestation affects the expression of key pancreatic β-cell genes and the methylation status of the regulatory region of the MafA gene in the offspring of Wistar rats2023 · 8 citations
  3. 3The Impact of Low-Protein Diet on the Molecular and Cellular Development of the Fetal Kidney2026 · 3 citations
  4. 4Maternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner2024 · 6 citations
  5. 5Obesity-Associated Gestational Diabetes Promotes Cellular Heterogeneity and Dysfunction in Neonatal Offspring-Islets2026 · 1 citations