Answers are grounded in this paper and cite their sources.
The IGF1-PI3-K pathway demonstrates beneficial effects in preclinical heart disease models, suggesting potential therapeutic targets for maintaining contractile function and promoting regeneration.
The insulin-like growth factor 1 (IGF1)-phosphoinositide 3-kinase (PI3-K) pathway is a critical regulator of cell and organ growth. 2. In the heart, the IGF1-PI3-K pathway induces physiological heart growth with preserved or enhanced cardiac function. 3. The present review specifically discusses the role of the IGF1-PI3-K pathway in the setting of heart disease. 4. Genetic mouse models have highlighted the beneficial effects of the IGF1-PI3-K pathway in the heart in a setting of disease. These include maintenance of contractile function, antifibrotic and anti-apoptotic actions, inhibition of signalling transducers activated in disease settings and regeneration.
No takes yet. Share an insight, caveat, or question.
Julie R. McMullen (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: