Key result
PI3K isoforms play distinct roles in cardiac hypertrophy and failure, acting through both kinase activity and protein-protein interactions.
Design
Review
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May guide isoform-selective PI3K targeting in research; leaves open clinical translation in heart failure.
Understanding the kinase-independent scaffold functions of PI3K isoforms provides deeper insight into the molecular mechanisms of cardiac hypertrophy and heart failure.
Damilano et al. (2010) conducted a review in Cardiac hypertrophy and failure. PI3K signaling was evaluated. PI3K isoforms play distinct roles in cardiac hypertrophy and failure, acting through both kinase activity and protein-protein interactions.
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