Key result
PI3K enzymes present potential therapeutic targets for thrombosis, atherosclerosis, and heart failure, though developing drugs against these master cellular regulators remains challenging.
Why the study?
The (patho)physiological roles of PI3K enzymes in the cardiovascular system make them potential therapeutic targets in thrombosis, atherosclerosis, and heart failure.
Design
Review
Authors
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Highlights PI3Ks as therapeutic targets in thrombosis and atherosclerosis; leaves open clinical translation pending isoform-specific trials.
This review highlights the potential of targeting PI3K enzymes for therapeutic benefit in cardiovascular diseases such as thrombosis, atherosclerosis, and heart failure, while acknowledging the challenges of developing drugs against these regulators.
Durrant et al. (2020) conducted a review in Thrombosis and cardiovascular disease. PI3K inhibitors was evaluated. PI3K enzymes present potential therapeutic targets for thrombosis, atherosclerosis, and heart failure, though developing drugs against these master cellular regulators remains challenging.
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