Population
conscious, chronically instrumented sheep
Design
Preclinical
Follow-up
60 min
Authors
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ANP's hemodynamic effects precede renal natriuresis at lower doses in sheep; leaves open translation to human dosing or mechanisms.
In a sheep model, ANP lowers blood pressure primarily by acting on the venous circulation to reduce venous return and cardiac output, with cardiovascular effects occurring at lower doses than renal effects.
Parkes et al. (1987) studied this question.
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