Population
Coronary arteries from lean and obese male Ossabaw miniature swine (porcine model of metabolic syndrome)
Comparison
Capsaicin (TRPV1 agonist) vs Lean pigs vs obese pigs; use of TRPV1 antagonist…
Design
Preclinical
Authors
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May impair coronary vasomotor function in metabolic syndrome; leaves open whether TRPV1 modulation benefits patients.
Metabolic syndrome impairs TRPV1-mediated, endothelium-dependent coronary vasodilation through decreased TRPV1 expression and cation influx in a porcine model.
Bratz et al. (2008) studied this question.
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