January 1, 1996British Journal of PharmacologyOpen Access

Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle

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Population

Smooth muscle cells enzymatically isolated from the rat basilar artery and basilar artery segments

Comparison

NS1619 at various concentrations vs Control conditions and application of channel…

Design

Preclinical

Authors

MHMichael B. HollandAllergan (United States)PLPhilip D. LangtonUniversity of Bristol NSNicholas B. StandenUniversity of Leicester

Discussion

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Implication

Should not change cerebrovascular practice; hypothesis-generating for BKCa modulation in cerebral vasorelaxation.

Structured PICO

Population

Smooth muscle cells enzymatically isolated from the rat basilar artery and basilar artery segments

Intervention

NS1619 (putative activator of large conductance calcium-activated potassium channels, BKCa) at various concentrations (0.3-100 microM)

Comparator

Control conditions (washout) and application of channel inhibitors (iberiotoxin, glibenclamide, apamin)

Outcome

Membrane potential, whole cell outward currents, single channel open probability, and vasorelaxationsurrogate

NS1619 induces vasorelaxation in rat basilar arteries through a combination of direct BKCa channel activation and inhibition of Ca2+ and voltage-activated K+ channels.

Cite This Study

Holland et al. (1996) studied this question.

synapsesocial.com/papers/6a71504435aa2c282ce29ec7 https://doi.org/10.1111/j.1476-5381.1996.tb15163.x

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Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider