December 1, 1994British Journal of PharmacologyOpen Access

Ion channel modulation by NS 1619, the putative BKCachannel opener, in vascular smooth muscle

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Population

Rat intact portal veins and single smooth muscle cells enzymatically separated from the same tissue

Design

Preclinical

Authors

GEG. EdwardsUniversity of Denver ANA. Niederste‐HollenbergHeinrich Heine University Düsseldorf JSJay W. SchneiderPreventive Cardiology

Discussion

Member takes

Implication

NS 1619's off-target inhibition cautions against BKCa-specific interpretations in vessels; leaves open the need for selective agonists in vascular research.

Structured PICO

Population

Rat intact portal veins and single smooth muscle cells enzymatically separated from the same tissue

Intervention

NS 1619 (3-100 microM)

Outcome

Ion channel modulation (BKCa, KV, L-type Ca-channels) and mechanical tensionsurrogate

NS 1619 acts not only as a BKCa channel opener but also inhibits KV and L-type Ca-channels, which likely accounts for its mechanical inhibitory effects in vascular smooth muscle.

Cite This Study

Edwards et al. (1994) studied this question.

synapsesocial.com/papers/6a71504435aa2c282ce29ec9 https://doi.org/10.1111/j.1476-5381.1994.tb17171.x

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Implication

NS 1619's off-target inhibition cautions against BKCa-specific interpretations in vessels; leaves open the need for selective agonists in vascular research.

Ion channel modulation by NS 1619, the putative BKCachannel opener, in vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ion channel modulation by NS 1619, the putative BKCachannel opener, in vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider