The developed mathematical model provides a realistic simulation of cerebral hemodynamics and systemic cardiovascular responses during severe head injuries.
Provides a simulation framework for cerebral hemodynamics in head injury; hypothesis-generating and requires clinical validation before any practice implications.
In this paper, a mathematical model for the description of cerebral hemodynamics is developed. This model is able to simulate the regulation mechanisms working on the small cerebral arteries and arterioles, and thus to adapt dynamically the blood flow in brain. Special interest is laid on the release of catecholamines and their effect on heart frequency, cardiac output and blood pressure. Therefore, this model is able to describe situations of severe head injuries in a very realistic way.
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Daun et al. (2005) studied this question.
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