Key result
A coupled 1D and lumped-parameter computational model successfully simulated cerebral blood flow changes during MCA and CCA occlusions, demonstrating the compensatory roles of cortical collateral flow and the circle of Willis.
Population
Computational model of the cerebral circulation
Comparison
Simulated occlusions in the middle cerebral… vs Baseline condition
Design
Preclinical
Authors
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May inform collateral assessment in cerebral occlusion; extends computational modeling but leaves clinical translation open.
This computational model provides insights into cerebral hemodynamics and autoregulation during arterial occlusions, highlighting the distinct compensatory roles of cortical collaterals and the circle of Willis.
Ryu et al. (2015) studied Cerebral hemodynamics (computational model). Simulated middle cerebral artery (MCA) and common carotid artery (CCA) occlusions vs. Baseline (healthy) conditions was evaluated on Changes in cerebral blood flow and velocity waveforms. A coupled 1D and lumped-parameter computational model successfully simulated cerebral blood flow changes during MCA and CCA occlusions, demonstrating the compensatory roles of cortical collateral flow and the circle of Willis.
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