Mathematical modeling suggests that rodent injury models may not accurately predict human physiology following traumatic brain injury due to differences in cerebral hemodynamics.
Rodent TBI models may not capture human ICP dynamics; leaves open translational validity of rat studies for plateau waves.
Mathematical models of cerebral hemodynamics, applicable to humans and rats have been developed and analysed with the purpose of reaching a deeper insight to which degree experimental results on rats can be extrapolated to humans and to clinical management of patients. These models include regulation mechanisms involving the small cerebral arteries and arterioles, flow autoregulation, as well as CO 2 and NO reactivity. Bifurcation analysis was conducted on both models. The human model includes Hopf‐bifurcations, which allow for the existence of periodic solutions with a time scale comparable to Lundberg′s plateau waves in intracranial pressure ( P ic ). By contrast, the rat model does not manifest Hopf‐bifurcations and thus does not predict the existence of periodic solutions with critical high P ic . Therefore the model questions the relevance of rodent injury models to predict human physiology following TBI.
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Daun et al. (2007) studied this question.
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