March 1, 2002AJP Regulatory Integrative and Comparative Physiology

Chronic measurement of cardiac output in conscious mice

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Population

Mice >30 g body weight, including intact mice and mice with myocardial infarction induced by coronary artery…

Comparison

Implantation of transit-time flow probes or… vs Echocardiography, electromagnetic flow probes…

Design

Preclinical

Follow-up

6-16 days after surgery

Authors

BJBen JanssenMaastricht University Medical Centre JDJacques DebetsMaastricht University PLPeter LeendersMaastricht University

Discussion

Member takes

Implication

Supports chronic CO monitoring in conscious murine HF models; leaves open clinical translation.

Structured PICO

Population

Mice >30 g body weight, including intact mice (n=15) and mice with myocardial infarction induced by coronary artery ligation 3 weeks prior (n=7)

Intervention

Implantation of transit-time flow probes or electromagnetic probes on the ascending aorta

Comparator

Echocardiography (for stroke volume comparison), electromagnetic flow probes (for cardiac output comparison), and noninfarcted mice (for MI comparison)

Outcome

Measurement of stroke volume (SV) and cardiac output (CO)surrogate

Chronic measurement of cardiac output using transit-time flow probes is feasible and reliable in conscious mice, including those with heart failure.

Cite This Study

Janssen et al. (2002) studied this question.

synapsesocial.com/papers/6a7150baac440176ef29fdcf https://doi.org/10.1152/ajpregu.00406.2001

Topics

Echocardiography

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