Why the study?
While smaller intervention trials have shown a decrease in pancreatic fat content with weight loss, the effects of weight loss on pancreatic fat content needed investigation in a larger trial.
Does diet-induced weight loss reduce pancreatic fat content in non-diabetic obese adults?
Does diet-induced weight loss reduce pancreatic fat content in non-diabetic obese adults?
Diet-induced weight loss decreases pancreatic fat content, but this reduction is driven by concurrent reductions in visceral adipose tissue rather than being an independent effect.
Weight loss reduces pancreatic fat in obese adults; extends smaller trials by linking effect to visceral adipose tissue reduction in this RCT.
BACKGROUND: Obesity can lead to ectopic pancreatic fat accumulation and increase the risk for type 2 diabetes. Smaller intervention trials have shown a decrease in pancreatic fat content (PFC) with weight loss, and we intended to investigate the effects of weight loss on PFC in a larger trial. METHODS: Data from the HELENA-Trial, a randomized controlled trial (RCT) among 137 non-diabetic obese adults were used. The study cohort was classified into 4 quartiles based on weight change between baseline and 12 weeks post-intervention. Changes in PFC (baseline, 12 weeks and 50 weeks post-intervention) upon weight loss were analyzed by linear mixed models. Spearman's coefficients were used to obtain correlations between anthropometric parameters, blood biochemical markers, and PFC. RESULTS: = 0.01) greater in Q4 (-30.8 ± 5.7%) than in Q1 (1.3 ± 6.7%). These differences remained similar after one year. However, when adjusting the statistical analyses for changes in VAT, the differences in PFC between Q1 and Q4 were no longer statistically significant. CONCLUSION: Weight loss is associated with a decrease in PFC. However, the reduction of PFC is not independent from reductions in VAT. Unlike VAT, PFC was not associated with metabolic biomarkers.
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Jiang et al. (2019) studied this question.
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