Why the study?
Does the use of clotting factor concentrates effectively and safely reverse oral anticoagulation in bleeding patients?
Population
18 patients requiring oral anticoagulation reversal due to major bleeds, minor bleeds, or emergency invasive…
Design
Cohort
Follow-up
immediate post-infusion
Authors
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Associated with prompt INR correction without thrombosis; leaves open randomized confirmation of net clinical benefit in bleeding patients.
Does the use of clotting factor concentrates effectively and safely reverse oral anticoagulation in bleeding patients?
Clotting factor concentrates provide a rapid and effective means for oral anticoagulation reversal with immediate reduction in INR and no observed thrombotic complications.
Niţu et al. (1998) studied this question.
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