Key result
Three-factor PCC effectively reverses emergency oral anticoagulation to mean INR <2.0 despite frequent guideline deviations.
Why the study?
Does three-factor prothrombin complex concentrate effectively and safely reverse oral anticoagulation in patients with critical bleeding or requiring emergency surgery?
Population
47 patients receiving oral anticoagulant therapy who required rapid reversal of anticoagulation due to…
Design
Cohort
Follow-up
In-hospital (mean 4.5 days for patients who died)
Authors
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Retrospective audit of PCC for OAT reversal highlights potential guideline gaps; leaves open need for standardized protocols and prospective outcome data.
Observational (n=47)
No
Does three-factor prothrombin complex concentrate effectively and safely reverse oral anticoagulation in patients with critical bleeding or requiring emergency surgery?
Three-factor prothrombin complex concentrates effectively and safely reduced INR in patients requiring emergency reversal of oral anticoagulation, though real-world hospital protocols often deviated from established guidelines.
Barillari et al. (2012) conducted an observational in Patients receiving oral anticoagulant therapy requiring rapid reversal due to emergency surgery or critical hemorrhage (n=47). Prothrombin complex concentrates (PCC) vs. None (before-after comparison) was evaluated on Compliance with international and national guidelines for emergency reversal of oral anticoagulation, and efficacy in reducing INR. Three-factor prothrombin complex concentrates effectively reversed oral anticoagulation in emergencies, reducing mean INR to <2.0, despite frequent deviations from administration guidelines.
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