March 13, 2008Journal of Thrombosis and HaemostasisOpen Access

Prothrombin complex concentrate (Beriplex® P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial

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Why the study?

Does prothrombin complex concentrate improve INR normalization and hemostatic efficacy in patients on oral anticoagulant therapy requiring emergency reversal?

Population

43 patients receiving antivitamin K oral anticoagulant therapy with INR > 2 requiring either an emergency…

Design

Cohort

Follow-up

48 hours

Authors

IPIngrid PabingerVascular Medicine BBBenjamin BrennerVascular Medicine UKUwe KalinaPhilipps University of Marburg

Discussion

Member takes

Implication

Supports PCC for urgent VKA reversal; extends observational data but leaves open randomized outcome confirmation.

Structured PICO

Does prothrombin complex concentrate improve INR normalization and hemostatic efficacy in patients on oral anticoagulant therapy requiring emergency reversal?

Population

43 patients receiving antivitamin K oral anticoagulant therapy (OAT) with INR > 2 requiring either an emergency surgical or urgent invasive diagnostic intervention or INR normalization due to acute bleeding. Multinational.

Intervention

Prothrombin complex concentrate (PCC) containing coagulation factors II, VII, IX, and X, and anticoagulant proteins C and S. Infused at stratified doses of 25, 35, or 50 IU kg−1 based on initial INR.

Outcome

INR normalization (≤1.3) by 30 min after PCC infusion and hemostatic efficacysurrogate

Prothrombin complex concentrate provides rapid and effective emergency reversal of vitamin K antagonist therapy, achieving INR normalization in 93% of patients within 30 minutes.

Cite This Study

Pabinger et al. (2008) studied this question.

synapsesocial.com/papers/6a212daf2c7e251d79c3d3cd https://doi.org/10.1111/j.1538-7836.2008.02904.x

Topics

Pulmonary embolism

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Prothrombin complex concentrate (Beriplex® P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Prothrombin complex concentrate (Beriplex® P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider