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January 1, 2007Pathophysiology of Haemostasis and ThrombosisOpen Access

Prothrombin Complex Concentrates for Urgent Anticoagulation Reversal in Patients with Intracranial Haemorrhage

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Key result

Prothrombin complex concentrates rapidly reversed oral anticoagulation in patients with intracranial haemorrhage, achieving an INR ≤ 1.5 in 75% of patients at 30 minutes with no thrombotic events.

Why the study?

Does prothrombin complex concentrate administration effectively and safely reverse oral anticoagulant therapy in patients with intracranial haemorrhage?

Population

92 patients suffering from acute intracranial haemorrhage while receiving oral anticoagulant therapy with an…

Design

Cohort

Follow-up

Hospitalization (up to 96 hours for INR monitoring)

Authors

DIDavide ImbertiGBGiovanni BarillariCBChiara Biasioli

Discussion

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Overview

May support PCCs for OAT reversal in ICH; leaves open need for randomized confirmation.

Study Design

Type

Cohort (n=92)

Structured PICO

Does prothrombin complex concentrate administration effectively and safely reverse oral anticoagulant therapy in patients with intracranial haemorrhage?

P
Population
92 patients (mean age 74 years) with acute intracranial haemorrhage while receiving oral anticoagulant therapy and an initial INR ≥ 2.0.
E
Exposure
Prothrombin complex concentrates (PCCs) infused at stratified doses of 35-50 IU kg(-1) based on initial INR.
O
Outcome
Rapid reversal of OAT (measured by INR reduction) and safety (thrombotic complications, adverse events, mortality).surrogate

PCC administration provides rapid, effective, and safe reversal of oral anticoagulation in patients presenting with acute intracranial hemorrhage.

Cite This Study

Imberti et al. (2007) conducted a cohort in Intracranial haemorrhage (ICH) during oral anticoagulant therapy (n=92). Prothrombin complex concentrates (PCCs) was evaluated on INR ≤ 1.5 at 30 minutes post-infusion. Prothrombin complex concentrates rapidly reversed oral anticoagulation in patients with intracranial haemorrhage, achieving an INR ≤ 1.5 in 75% of patients at 30 minutes with no thrombotic events.

synapsesocial.com/papers/6a658a8d1a73af1ea1b69fd7https://doi.org/10.1159/000252822
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